and, most importantly, we see the same senitization to 5FU with other CI inhibitors, such as IACS-010759, phenformin and carboxyamidotriazole, as we do with metformin
One study found that 88% of patients with autism had deficiencies in the electron transport chain complexes I, III, and/or IV [92,95]
Under hypoxia, HIF-1 is stabilized by low COMMD10 expression, promoting the transcription of ceruloplasmin and SLC7A11 and inhibiting ferroptosis in HCC
From there, you can chat with a clinician about options like magnesium glycinate or non-hormonal prescription medications that target vasomotor symptoms like night sweats (such as Veozah or certain SSRIs/SNRIs)
10.1021/acs.orglett.4c00103