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Ozempic and Mounjaro are formally approved for type 2 diabetes, though their pronounced weight-loss effect has made off-label use for obesity extremely common worldwide

As Stephen Lawrence, associate clinical professor at Warwick Medical School in Coventry, UK, points out when used in accordance with prescribed guidelines, it promotes weight loss in a safe and effective way for most people, and the treatment has already been used in T2DM

We speculate that LC may improve myocardial metabolic remodeling by inhibiting PI3K/Akt signal transduction, which could be linked to increased expression of the mitochondrial key regulator PGC-1

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