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Sp could also increase the efficacy of L-DOPA, extensively used in palliative care of PD patients, by subsidence of its long term toxicity

Many other intranasal preparations using specialized delivery systems involving nanoparticles are being assessed in laboratory and sometimes human trials across a range of diseases

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They tend to reduce excessive inflammatory signaling without eliminating protective immunity

Phase I and phase II trials are also underway to assess the safety and pharmacokinetics of small molecule inhibitors of LOXL2, such as GB2064 (NCT04679870) and PXS-5382 A (NCT04183517)