In a combined fertility and prenatal and postnatal study in male and female rats at subcutaneous doses up to 0.36 mg/kg/day, which was approximately 50 times the recommended human subcutaneous starting dose of 0.2 Units/kg/day (0.007 mg/kg/day), maternal toxicity due to dose-dependent hypoglycemia, including some deaths, was observed
It may have nothing to do with the B12 itself
To counteract this process, the body has to produce new molecules of glutathione
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Juei-Tang Cheng Joshua Reed, Stephen C Bain, Venkateswarlu Kanamarlapudi Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK Correspondence: Venkateswarlu Kanamarlapudi, Institute of Life Science, Medical School, Swansea University, Swansea, SA2 8PP, UK, Tel +44 1792 295012, Fax +44 1792 602148, Email [email protected] Abstract: In healthy humans, the complex biochemical interplay between organs maintains metabolic homeostasis and pathological alterations in this process result in impaired metabolic homeostasis, causing metabolic diseases such as diabetes and obesity, which are major global healthcare burdens
