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What Clotting Time Assesses Coagulation factors (especially intrinsic pathway) Overall clot formation Causes of Prolonged Clotting Time Hemophilia (factor VIII or IX deficiency) Severe liver disease Vitamin K deficiency Heparin therapy Disseminated intravascular coagulation (DIC) Clinical Uses Historical screening of coagulation disorders Limitations Low sensitivity Cannot localize specific factor deficiency Largely replaced by PT/INR and aPTT Normal Values Bleeding time: 27 minutes Clotting time: 515 minutes (method-dependent) Prolonged BT + normal CT platelet disorder Normal BT + prolonged CT coagulation factor deficiency Both prolonged severe coagulation disorders PT/INR and aPTT are preferred modern tests To view or add a comment, sign in Incretin Therapies: Key Milestones 1960s1980s: Incretin effect described 2005: First GLP-1 RA reaches market (exenatide) 2010s: Longer-acting GLP-1 RAs proliferate

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Current trend: Moderate growth, supported by aging population and chronic disease prevalence