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During the 1990s, endocrinologists were looking for a hormone similar enough to the humans gut GLP-1, identified in 1986 this hormone was attractive as it stimulated insulin only when blood sugar levels were high

After every bowel movement, clean the anal area with a witch hazel pad, a soothing baby wipe or a cotton cloth soaked in warm water

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For some, these effects are interpreted as signs of drug efficacy or commitment to weight loss, whereas others experience them as discomforting or harmful