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It was co-founded by Massachusetts Institute of Technology professor Leonard Guarente, Sinclairs former research adviser and an investor in Sinclairs Sirtris

Kishi Y, Schmelzer JD, Yao JK, et al

Figure 5 An extension of the enhancement of Ang II Ang II is the main effector of the renin-angiotensin-aldosterone system (RAAS), and studies have shown that Ang II promoted the development of hypertension through RAAS system (118)