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Higher Risks of Eye Damage in Diabetic Patients A new study published in Jama Ophthalmology has found that after six months of use GLP-1 receptor agonists (RA) are associated with double the risk of older people with diabetes developing neovascular age-related macular degeneration compared with similar patients not taking the drugs

For both therapeutic classes, this increased risk of gallbladder or biliary diseases has been thought to be driven by the inhibition of the secretion of cholecystokinin by GLP-1, leading to impaired gallbladder motility and contractility [64, 65]

In a Phase III study of 187 PAH patients comparing Opsynvi to macitentan and tadalafil monotherapy, J&Js drug was superior in n reducing pulmonary vascular resistance

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