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Fatigue accompanied by anhedonia, sleep disturbances, or changes in appetite beyond those expected from the medication warrants evaluation for depression, potentially using validated screening tools like the PHQ-9

Semaglutide-related fatigue is often related to reduced caloric intake rather than a direct drug effect, and adjusting protein intake or meal timing can help

Last reviewed: May 25, 2026 Last updated: May 25, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Segerstolpe , Palasantza A, Eliasson P, et al

Innovation in formulation and packaging is further driving growth, with brands targeting fitness enthusiasts and younger consumers by promoting yerba mate's energizing and antioxidant properties