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The gut microbiome, as the second genome, plays an important role in dynamically integrating signals from the host and its environment, impacting both physiological homeostasis and disease emergence ( Changes in gut microbiota alter the production of gut metabolites and thus affect the development of CVDs ( Although the role of TMAO in CVDs is well established, detailed understanding of how TMAO regulates the development and progression of CVDs has yet to be elucidated

However, when the integrity of the intestinal barrier is damaged, the submucosal immune cells are exposed to bacteria, dietary antigens and autoantigens, which can result in adverse immune activation or tolerance response failure, leading to autoimmune diseases [79]

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10 NUTRITIONAL SUPPLEMENTS AND METABOLIC SYNDROME