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Jensen TP, Filoteo AG, Knopfel T, Empson RM

postulated the role of indoxyl sulfate in the pathogenesis of renal anemia: indoxyl sulfate could stimulate oxidative stress and induce eryptosis through Organic Anion Transporter 2 (OAT2)- and NADPH oxidase-dependent, as well as GSH-independent mechanisms [257]

The reduction in Adenosine Triphosphate (ATP) synthesis, resulting from the disruption of electron transport chain function, leads to disorders in cellular energy metabolism, thereby affecting the normal physiological functions of cells (68)

Alpha Lipoic Acid: Powerful antioxidant supporting detoxification

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