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Interestingly, weight loss generally reduces GERD severity over time, so while early GI effects of tirzepatide may transiently worsen symptoms, long-term weight reduction might ultimately improve reflux for many patients

Other common side effects have included indigestion, headache, constipation, abdominal pain, dyspepsia, vomiting, and injection site reactions, such as redness or itching at the injection site

Gachiani J, Kim D, Nelson A, et al