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Lancet 2022;400:186981.ArticlePubMed 114

Released in response to food intake, these hormones enhance glucose-dependent insulin secretion, playing an essential role in maintaining normal glucose homeostasis (40)

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These results provide clues to neural mechanisms that support the development of GLP- 1 and GIP combination therapeutics for the treatment of obesity and DM [79]

5,877,289 and 6,342,221, in particular, are specifically incorporated herein by reference for the purpose of further describing and enabling how to make and use antibody constructs that comprise a selectively-cleavable peptide linker that is cleaved by urokinase, plasmin, Thrombin, Factor EXa, Factor Xa or a metalloproteinase, such as an interstitial collagenase, a gelatinase or a stromelysin, within a tumor environment