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Its a lot harder without the help of tirzepatide, but I listen to my body and its hunger cues, stop eating when Im full (even if theres still food on my plate), and continue to move my body in fun ways

We dont have evidence that giving a healthy human an injectable GLP-1 agonist will directly increase their VO2max or endurance capacity and in fact, what limited human data we have suggests no performance boost

Such that, the secretion of inflammatory cytokines, such as tumor necrosis factor- (TNF), would lead to neuroinflammation and migraine episodes by increasing the cellular permeability and interactions (11, 12)

Acknowledgments Tianqi Liu, Ying Liu, Xiaoyu Zhao contributed equally to this work

Smaller, more frequent meals are generally better tolerated than large ones because GLP-1 medications slow gastric emptying