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Contemporary technologies and non-ionizing radiation have become more prevalent daily, leading to detrimental consequences on the body
doi: 10.1016/s0028-3908(01)00056-9
Trial Design Considerations REDEFINE-1 Used Flexible Dosing: Investigators could reduce dose if patients experienced intolerable side effects
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The appetite effect is a matter of neural signaling: area postrema neurons project to the parabrachial nucleus and onward to forebrain regions that govern the decision to stop eating, and this circuit also engages hedonic pathways that reduce the rewarding value of food
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