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In this last case, transmethylation capacity is limited because the tissue distribution of the enzyme is restricted to specific organs (Delgado-Reyes et al., 2001)
A recent study showed that glucose metabolism was dysregulated and that pyruvate supplementation could prevent neurodegeneration in an animal model of glaucoma 31 , suggesting that ATP production from glycolysis is disrupted, and that other energy fuel pathways, such as -oxidation, may be augmented to compensate for the reduction in energy metabolism
Further, it suggests that the inflammatory response is also independent of plaque burden
N Engl J Med (2021) 385(1):e4
ParkHCYoonHBSonMJJungESJooKWChinHJet al
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