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Significantly, while NE stimulation causes receptor recruitment of -arrestin2 (EC 50 = 3.1 0.001 M), DA stimulation does not (Fig

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Various types of stimulation, such as X-ray irradiation, mechanical stress and genetic variations, can induce cell death by inducing the expression of pro-apoptotic genes, reaper 5 , hid 6 , and grim 7 (RHG proteins), and finally by activating Caspases which degrade cellular substrates