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Notably, the deletion of lipogenic enzymes in the liver, such as acetyl-CoA carboxylase 1/2 (ACC1/2), has been reported to liberate NADPH for antioxidant processes, including GSH regeneration 87

injection of L2-Cmu ( n = 6) at a dose of 20 mg/kg or vehicle ( n = 9) 5 days after surgery

The correct approach: Test serum B12, MMA, and homocysteine not just serum B12 Use the functional cutoff of 500 pg/mL for optimal status, not the labs lower limit of 200 pg/mL Identify the cause diet, malabsorption, medication, or autoimmune Match the supplementation protocol to the cause and severity Retest to confirm response, and continue monitoring if the underlying cause persists If youre over 50, vegan, taking metformin or PPIs, or experiencing unexplained fatigue, brain fog, or neuropathy get tested

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Two key findings reinforce this conclusion