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The mechanism is primarily through the increased accumulation of S-adenosyl-L-homocysteine (SAH), a compound that is a noncompetitive inhibitor of DNMT, which inhibits the DNA methylation response [81]

Other structures used in this study were obtained from the PDB with accession codes 6U7M (LPL helix), PDB 6OB0 (LPL with GPIHBP1), 1LPA (PTL/procolipase complex), and 1ETH (porcine PTL)

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Vomiting Diarrhea Constipation Indigestion Decreased appetiteLess Common but Serious Side Effects: Hypoglycemia (low blood sugar): Especially when used in combination with other diabetes medications like insulin

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