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This oxidation of proteins may create reactive and toxic oxygen species, such as hydrogen peroxide, leading to direct cell toxicity and apoptosis,

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"Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation

Patients who stay at 2.5 mg are operating outside the studied protocol, though closer to the evidence base than someone taking 0.125 mg of semaglutide