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Out of 19 studies comprising randomized clinical trials (RCTs), systematic reviews, and meta-analyses, 10 RCTs, both double-blind placebo-controlled and non-double-blind placebo-controlled, were included which were conducted on nutraceuticals primarily consisting of the bioactive components CoQ10 (ubiquinol), flavonoids, curcumin, and polyphenols in CKD patients to identify the renoprotective benefits of these bioactive components on the initial stages of CKD without displaying any kind of side effects in the participants

doi: 10.1097/MD.0000000000035503 347 HuangJZhangJWangFZhangBTangX

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However, a review of recent studies indicates that this is soon to change as more clinicians become aware of the unique advantages of nasal delivery of peptides and other therapeutics