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Inborn errors of energy metabolism associated with myopathies

Some warrant medical attention

Claims around peptides often outpace what research actually supports, as experts like Stuart Phillips highlight

Further investigations to fully elucidate the effect of the V229A substitution on GLP-1R-cholesterol interactions might include detailed atomistic MD simulations of WT versus V229A receptors, as well as resolving cryo-EM structures of mutant and WT receptors in nanodiscs containing relevant lipid compositions to preserve receptor-lipid interactions in their native environment