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Whereas the result of ACCORD must be interpreted carefully because it might have been influenced by the lack of statistical power for assessing cardiovascular events and the effects of baseline characteristics like statin or aspirin use, most of current guidelines generally do not recommend maintaining systolic blood pressure less than 120 mmHg to reduce mortality or cardiovascular disease other than stroke considering adverse events related to antihypertensive therapy, such as worsening renal function and electrolyte abnormalities
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Long-term incubation of human erythrocytes with aluminum induced PS externalization, increased intracellular Ca 2+ levels, and degradation of AE1 proteins, which are markers of eryptosis
