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Luteinizing hormone-releasing hormone (LH-RH) and growth hormone-releasing hormone (GH-RH) are critical in regulating growth hormone (GH) secretion and have been implicated in aging-related processes

The human gene encodes for two isoforms of the enzyme, namely PEMT1, which is localized in the endoplasmic reticulum and generating most of the PEMT activity, and PEMT2, a liver specific isoform exclusively localized in mitochondriaassociated membranes (Tessitore et al., 2003)

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