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GI side effects: Nausea, vomiting, and diarrhea can increase fluid loss and contribute to dehydration

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Because sitagliptin is substantially excreted by the kidney, and because aging can be associated with reduced renal function, renal function should be assessed more frequently in elderly patients [see Dosage and Administration (2.2), Warnings and Precautions (5.3)]

Table 2 shows common adverse reactions in adults associated with the use of dapagliflozin and metformin HCl