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48 There is a circumscribed subjacent proliferation of mitotically active melanocytes (Figure 10) that extends to lie in direct apposition to either a smooth, papillomatous or verrucous epidermis

Edmiston, MD, para a Peptide Sciences

Nevertheless, it is still needed to be elucidated whether these two oncogenic signaling pathways possess any initiating roles in the development of cancer or they are merely contributing molecules in the propagation of tumors or development of resistance to existing therapeutic agents

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