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An analysis of the activity of AKT1 and AMPK, known regulators of mTORC1, showed no consistent changes in p-AKT1-S473 and unchanged levels of p-AMPK-T172 in aneuploid cells compared to their diploid parental cells

this created a controversy that arguably slowed progress toward establishing EAAT2 as a therapeutic target in ALS [395, 396]

Lledo-Garcia R, Kalicki RM, Uehlinger DE, Karlsson MO

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Apoptosis, on the other hand, is distinguished by the cleavage of certain substrates and the activation of caspases