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This so-called within-batch effect, decreases the repeatability and reproducibility as well as the discriminant power to detect relevant biological responses, and difficults data interpretation and reuse

We also solicited comments in the CY 2023 PFS proposed rule on when and how to best incorporate the 2017-based MEI into PFS ratesetting, and whether it would be appropriate to consider a transition to full implementation for potential future rulemaking

Fit-for-purpose models: In vivo required for multi-organ pharmacology

Funding This work was supported by grants from the National Natural Science Foundation of China, Youth Project (#82004337)

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