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ACh: acetylcholine AD: Alzheimers disease ANS: autonomic nervous system ASM: airway smooth muscle BBB: blood-brain barrier CNS: central nervous system dMRI: diffusion-weighted MRI GFAP: glial fibrillary acidic protein GLP-1: glucagon-like peptide-1 GLP-1R: glucagon-like peptide-1 receptor GLP-1RAs: glucagon-like peptide-1 receptor agonists GPCR: G protein-coupled receptor HDM: house dust mite HFDs: high-fat diets IL-33: interleukin-33 MD: mean diffusivity NfL: neurofilament light chain PNS: peripheral nervous system SAMP8: senescence-accelerated mouse prone 8 T2DM: type 2 diabetes mellitus Th2: T-helper type 2 TNF-: tumor necrosis factor alpha VEGF: vascular endothelial growth factor WAT: white adipose tissue CL: Conceptualization, Writingoriginal draft, Writingreview & editing