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doi: 10.1136/gutjnl-2015-309990 46 MiyakeS.KimS.SudaW.OshimaK.NakamuraM.MatsuokaT.et al

These authors showed that visible HR following Tobacco mosaic virus (TMV) inoculation was preceded by a transient drop in antioxidant enzyme activities, e.g., APX, glutathione reductase (GR) and GST

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However, following exposure to stressors, Keap1 undergoes modifications that impair its ability to bind to and target Nrf2 for degradation