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While norepinephrine seemingly inhibits GLP-1 secretion via its action on -adrenergic receptors, its secretion is stimulated by isoproterenol, and this effect can be blocked by co-infusion of the -adrenergic receptor antagonist propanolol [337]

Human islets secreted over 10-fold more GLP-1 than mouse islets on a per islet basis (Fig