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This increase in glutamate likely results in increased efflux of doxorubicin from the cells, thereby decreasing toxicity (28)
APE1 was also one of the many non-regulatory proteins involved in cancer survival signaling pathways, and could be used as a therapeutic target in the treatment of multiple types of tumor cells [24]
However, the safety and efficacy of these combinations have not been extensively studied, and the decision to use multiple weight loss drugs should be made under close supervision by a qualified healthcare provider
