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August 20, 2008

Key mechanisms include the relief of hypothalamic-pituitary-ovarian (HPO) axis inhibition through weight loss and improved insulin sensitivity, alongside improved endometrial receptivity driven by increased SHBG and decreased free androgens (83, 167, 168)

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Though both the exposure and comparison cohorts were drawn from the same platform, which should not significantly impact the relative hazard rate ratios, results from the TriNetX platform need to be validated in other populations and platforms of EHRs