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Acetylcarnitine supplementation reduced both mental and physical fatigue, and improved health-related quality of life in people undergoing treatment for hepatitis C (the treatment for hepatitis C treatment produces symptoms that are similar to ME/CFS.) A large cancer study did not find, however, that 2g of L-carnitine a day improved fatigue in cancer patients and a meta-review did not support the use of carnitine for fatigue in cancer

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Fatigue typically emerges from metabolic adaptation, inadequate protein consumption, or rapid weight loss rather than GLP-1 directly suppressing energy pathways