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Such trials must rigorously evaluate the efficacy and safety of O-GlcNAcylation-targeting approaches in patients, with particular attention to CNS disorders where treatment options are limited

Reviewing the effects of L-leucine supplementation in the regulation of food intake, energy balance, and glucose homeostasis

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255 For example, the integrin-mediated signaling pathways regulate the expression of genes involved in collagen synthesis and degradation, influencing the mechanical properties of the ACL