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These criteria vary by brand, as each is formulated for a different use

For cannabis, the dose-response relationship is not linear like the monophasic dose-relationship

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Up to 55% of patients developed anti-drug antibodies [65], which were associated with systemic allergic reactions in approximately 5% of cases and injection-site hypersensitivity, including anaphylaxis, which necessitated early trial termination [66, 67]