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Early weeks focus on dose escalation to minimise gastrointestinal side effects

Sleep may be worse, heat can make hydration easy to miss, and appetite can swing from low hunger to cravings in the same few days

Diabetes 67(8):15381548 Reiner DJ et al (2016) Astrocytes regulate GLP-1 receptor-mediated effects on energy balance

1,5 Liter pro Tag), um eine mgliche Dehydrierung zu vermeiden Verabreichungszeitpunkt ndern Fettiges und frittiertes Essen meiden Stark gewrztes und riechendes Essen meiden Dosis anpassen (immer in rztlicher Absprache) Vermeide Getrnke mit Alkohol oder viel Kohlensure

Table 1 : Summary of SURPASS trials Effect on weight loss Currently the weight loss observed with semaglutide is greater than that reported for other approved anti-obesity medications