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A randomized trial published in the European Journal of Pain found that vitamin B12 significantly improved pain scores in patients with chronic low back pain compared to placebo

However, challenges such as high initial costs and limited acceptance decrease the generalization of bariatric surgery as a strategy to lower the obesity impact on public health

[55] There are clinical guidelines specifically to mitigate this risk in its use, [58] with doses limited to 510 mg orally before meals and at bedtime

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