107 ZhangY.HuangR.ChengM.WangL.ChaoJ.LiJ.et al (2019)
This is why a gradual escalation over 4-8 weeks is used to reduce the severity of adverse gastrointestinal effects compared to a rapid 2-week jump
Biochemical markers including triglycerides, total cholesterol, low-density lipoprotein cholesterol, glycated hemoglobin, and alanine aminotransferase levels showed significant reductions after GLP-1 RA treatment
The data indicated a positive correlation between the expression of PPAR and insulin-secretion-related genes, including IRS1 , GLUT2 , GCK , MAFA , PDX1 , Insulin ( INS ), Paired box 6 ( PAX6 ), and Potassium inwardly rectifying channel, subfamily J, member 11 ( KCNJ11 ) (Fig
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