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(2003) Randomized, placebo-controlled trial of intramuscular vitamin B12 for the treatment of hyperhomocysteinaemia in dialysis patients

Depression Vitamin B12 is necessary for the proper functioning of the brain

There are several different forms of B12 including cyanocobalamin (Cyano-B12), Methylcobalamin (Methyl B12), Hydroxocobalamin (Hydroxy-B12), and Adenosylcobalamin (Adeno-B12)

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect

Many plant-based milk alternatives, breakfast cereals, and nutritional yeast products contain added b12