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Ascorbate is found at highest concentrations within nucleated cells with the intracellular concentration being found on the order of 30-100 times the concentration found in the plasma

However, in insulin-resistant states, cells in the liver, muscles, and adipose tissue fail to respond efficiently to insulin, leading to hyperglycemia, dyslipidemia, and metabolic stress

Pharmacologic therapy for type 2 diabetes mellitus

Several types of cancer cells have been reported to have altered metabolism, such as high levels of iron uptake and ROS which make the cells sensitive to ferroptosis [251]