Lastly, among rats, the administration of wortmannin (a fungal metabolite) which induces hyperphosphorylation of tau in hippocampal pyramidal neurons, can be partly attenuated by preinjection of melatonin [117, 118], underscoring melatonins potential therapeutic role
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BrownJCMaCShiQFuchsCSMeyerJNiedzwieckiDet al
Caloric restriction mimicry: Some investigators have noted that the metabolic effects of glutathione repletion in older adults improved insulin sensitivity, reduced inflammation, enhanced mitochondrial function overlap substantially with known benefits of caloric restriction, suggesting that glutathione deficiency may partly mediate the metabolic decline of aging [10][11]
doi: 10.1111/1440-1681.12537 12 YangXChenWZhaoXChenLLiWRanJet al