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Using the medication past this date means you may be injecting a solution that is no longer sterile, which can lead to: Redness or swelling at the injection site Localized infections or abscesses More serious systemic reactions in rare cases Unpredictable Chemical Changes While it is rare for expired medications to become toxic, the chemical breakdown can lead to unpredictable side effects

After 30 min incubation at room temperature, the treated lysates were further divided into smaller aliquots (50 l), which were then heated at different temperatures for 3 min on a Veriti thermal cycler (Applied Biosystems) followed by cooling for 3 min to room temperature

Dispose of the pen 30 days after first use

Diabetes Care 34(6):12951300