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The low abundance of these modifications poses a significant challenge for comprehensive PTM proteomics analysis [101]

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Recent investigations have revealed that ferroptosis involves alterations in iron metabolism regulatory proteins (e.g., GPX4, TfR1), accumulation of lipid peroxidation products, and dysregulation of antioxidant systems, particularly the nuclear factor E2-related factor 2 (Nrf2)/glutathione peroxidase 4 (GPX4) pathway (8, 9)

Role of Oxidative Stress in Liver Disorders

eCollection 2021