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Circulating levels of soluble RAGE (sRAGE, a decoy receptor) are positively associated with acute respiratory distress syndrome severity and mortality risk, whereas reduction in circulating levels of sRAGE drop results in disease resolution

The P5P acts as the essential catalyst for the decarboxylation of 5-HTP, ensuring that the precursor is efficiently transformed into the serotonin needed to stimulate the 5-HT4 receptors and initiate healthy gut contractions

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