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Engagement of -glucans with Dectin-1 triggers tyrosine phosphorylation of an immunoreceptor tyrosine activation (ITAM)-like motif, which in turn recruits and activates the Syk tyrosine kinase, leading to activation of both NF-B and MAPKs through a signaling pathway mediated by Card9 and Raf (9, 1214)

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H., Hodgson, E

Both are building redundancy into their supply chains to prevent bottlenecks like those that plagued early launches