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By age 60, circulating GHK-Cu has dropped to roughly 20% of youthful levels
In the last few years, various GSH modulation-enhanced combinational therapy strategies have been extensively exploited, accompanied by the development of versatile metal-based nanosystems with different structures, functionalities, and treatment performances ( In view of the rapid development of GSH-responsive and -exhausting metal nanomedicines in potentiating cancer therapy, we summarize and outline the recent advancements, mechanisms, prospects, and challenges in this field from different strategies (Scheme 1)
The dual interaction of antimicrobial peptides on bacteria and cancer cells
The metabolomics data are available from MetaboLights under identifiers MTBLS12731, MTBLS12738 and MTBLS12741
Liposomal formulations, reduced glutathione variants, and alternative delivery routes (IV, intramuscular, nebulized) bypass this limitation but require clinical administration
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