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543 The JAK-STAT pathway serves as a hub for cytokine signaling, and inhibitors such as tofacitinib effectively block IL-6- and IL-23-mediated immune cell activation by competitively occupying the ATP binding site of the kinase

Pharmacogn Mag 8:156161 Zaharuddin ND, Noordin MI, Ali K (2014) The use of Hibiscus esculentus (Okra) gum in sustaining the release of propranolol hydrochloride in a solid oral dosage form

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Methotrexate, which carries the highest hepatotoxic risk among oral treatments, necessitates routine liver function testing at least every 3 months, while cyclosporine requires close monitoring of renal function and blood pressure due to its nephrotoxic potential (Warren et al