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Importantly, DSIP did not alter the rate of uncoupled respiration (VDNP), which is the oxygen consumption rate when the proton gradient is dissipated

While these findings provide biological plausibility for a direct cardiac mechanism, they do not demonstrate functional receptor activity or confirm that semaglutide acts directly on these cells

Cardiovascular Benefits: Semaglutide may reduce the risk of major cardiovascular events in those with type 2 diabetes and heart disease, offering comprehensive health improvements

[PMID:32597710] Benwood C, Chrenek J, Kirsch RL, et al

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