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The apparent increase in sensitivity to IGF-1 was dependent on a functional IGF-1R since as IGF-1 induced Akt and ERK phosphorylation was markedly attenuated by the treatment with PPP (Figure 4f and 4g)

Instead of mimicking GHRH, it binds to ghrelin receptors, triggering short, controlled pulses of growth hormone release

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To date, no studies have examined the length of time that test subjects may need to rest between different cycles of ipamorelin